RAF Typhoon jets have operated alongside French warplanes in a joint strike on an subterranean weapons facility in Syria employed by the IS group, as stated by the British defence ministry.
The location, located using surveillance, was thought to be storing arms and explosives, the release indicated, and was situated in mountainous terrain just above Palmyra in central Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to strike a number of access tunnels providing entry to the site... early reports indicate the strike was effective," the MoD said.
There was no evidence of any civilian impact in the attack late on Saturday and every plane involved made a safe return, the MoD added.
The British jets were backed up by a Voyager tanker plane.
Daesh - referred to as ISIS - imposed extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This action underscores the UK's leading role, and commitment to operate in unison with our allies, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the area," Britain's Defence Chief the minister said.
RAF aircraft have conducted patrols over Syrian airspace to "deter any efforts to regroup" of IS subsequent to its defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I extend gratitude to all the members of our armed forces participating in this strike for their professionalism and their courage," the Defence Secretary added. "They were part of numerous British troops deployed over Christmas and New Year. This mission, to take out militants who pose a risk to our security, shows how British military are always on standby, all year round, ensuring Britain's security domestically and influential overseas."
During December, the United States armed forces conducted what it called a "massive strike" against Daesh sites in the country, after an assault claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The UN reports Islamic State still maintains roughly 5-7 thousand combatants in both countries.
